The indeterminate growth habits of cotton often results in excessive vegetative growth. Under tropical conditions this excessive vegetative growth interferes with the penetration of pesticides to lower leaves to control insects and diseases, induces boll rot and interferes with mechanical harvest. The use of nitrogen fertilizers often aggravates the problem, particularly in fields with high plant density. This study used the Mepiquat Chlroride model named ‘Benchmark' to schedule the time and rate of MC applications in the State of Valle, Colombia. Plots receiving different levels of fertilizers, planted at various plant densities were used in the study to validate the model. Inputs necessary to run the Benchmark model are periodic measurements of plant height and number of main stem nodes. These measurements were collected at weekly intervals in all plots. Time and rate of MC applications were made based on model predictions to maintain plants at predetermined plant heights at the end of the season. Results will be presented in terms of the effectiveness of the model to predict final plant height at the end of the season and final lint yield and fiber quality per plot.