This study evaluated the effects of the protein enhancer Chaperone on cotton yield and fiber quality when applied alone and in tank mix with the foliar fertilizer CoRon 25-0-0. The study was conducted at a commercial farm in Nueces County, Texas during the 2005 growing season. Treatments were applied at early bloom and mid bloom and included single and double applications of Chaperone at 5.0 oz./acre, CoRon at 0.5 gal./ac, and their combined rates. Results from this study showed that Chaperone alone and CoRoN alone or in combination increased yields. Analysis of the effects on fiber properties is pending.