Genomic Mechanisms for the Evolution of Bt/Insecticide Resistance in US Cotton Bollworms: Humans to Insects

RNA Seq studies were conducted with primary human hepatocytes and the impact of pesticide exposure on global gene expression.  Our knowledge of the human genome is advanced and was used as a  model system to understand how genome organization might be a factor in pesticide exposure and potential the evolution of drug resistance.  These studies resulted in an understanding of a possible genome structure and how this structure might be involved in the evolution of insect resistance in insects.  Research is presented for similar studies in Bt resistant and susceptible US bollworms.  This has led to a hypothesis of how multiple Bt resistance mechanisms could involved as a result of insecticide selection in caterpillars.