Studies were conducted on the Texas High Plains in 2006 and 2007 to evaluate select weed management systems in strip-tillage cotton including glyphosate with preplant incorporated, preemergence, or postemergence residual herbicides.  Visual assessments of weed control and crop injury were made periodically throughout the growing season and yield data was collected at crop maturity.  Treatment efficacy as well as economic returns above weed management costs were observed.  Glyphosate in combination with residual herbicides provided better control than any other treatments.