J. Vincent Edwards1, Phyllis Howley2, Judy Arnold3, Nicolette Prevost1, and Jonathan Chen4. (1) SRRC, 1100 Robert E. Lee Blvd., P.O.Box 19687, New Orleans, LA 70124-4305, (2) Southern Regional Research Center, 1100 Robert E. Lee Blvd., New Orleans, LA 70124, (3) Richard Russell Research Center, 950 College Station Road, Athens, GA 30605, (4) Louisiana State University, School of Human Ecology, 143 HUEC Building, Baton Rouge, LA 70803
We have investigated the antibacterial and hemostatic properties of chitosan-grafted cotton fabrics. The antibacterial properties of chitosan placed on cotton with crosslinking chemistry appear to be dependent on the molecular weight of the chitosan, and sensitive to formulation and finishing methods. The hemostatic activity on the other hand that is observed with chitosan-grafted cotton is less sensitive to chemistry and formulation issues. In fact the promise to develop a hemostatic cotton fabric with chitosan is good.There are currently few cotton-based dressings that accelerate clotting appropriately for battlefield trauma. In addition the development of a military uniform fabric with in-situ wound response properties would be of interest to the armed forces. Mortality due to pre-hospital battlefield trauma has not improved much since World War II. It is thought that a fabric that accelerates clotting at the onset of wounding would improve the chances of survival. The growing market for interactive textiles, which includes wound response uniforms, is expect to reach $300 million dollars by 2009. The development of clothing containing clotting agents has more requirements for durability than a wound dressing. For example the hemostatic fabric that promotes thrombosis must withstand repeated laundering and be easily regenerable during washing. Cotton-based hemostatic clothing must meet the same requirement of comfort and breathability required of standard uniform clothing. The results of our findings on the antibacterial and hemostatic properties of chitosan grafted on woven fabrics will be presented.