Giant ragweed is becoming a more prevalent problem in cotton fields in Tennessee.  Historically, giant ragweed was mostly confined to field edges but in recent years has progressively spread into cotton fields.  One reason for this is that giant ragweed has a good level of natural tolerance to glyphosate.  In the Tennessee Weed Control Manual glyphosate is only listed as a 5 for control of giant ragweed on a 1 to 10 scale.  Therefore, research was conducted that examined giant ragweed control with several different herbicides in a cotton production system.  This research was conducted on a cotton field in Lauderdale county Tennessee that was heavily infested with giant ragweed. Results of this research will be discussed.