We will discuss the feasibility of using of islands-in-the-sea (I/S) fibers in the spunbond process to produce relatively high strength micro- and nanofiber webs. The relationships between the number of islands, percent polymer composition, and the fiber and fabrics properties are also reported. Nylon 6 (N6) and poly (lactic) acid (PLA) were used as the islands and sea polymers respectively. Micro- and nanofibers were obtained by dissolving PLA polymer from the final spunbond nonwovens. The fibers with 25% N6 showed a decrease in fiber diameter from 1.3 to 0.36 microns when the number of islands was increased from 36 to 360. The diameter of fibers with 75% N6 showed a decline from 2.3 to 0.5 micron for the same range. Hydroentangling was found to be a viable method of bonding of the I/S structures and the bonded structures were able to withstand post-processing steps required for dissolving of the sea from the resulting nonwovens. Hydroentanged micro- and nanofiber based nonwovens demonstrated high tensile and tear properties, which were insensitive to the N6 fiber size and its mechanical properties. Such insensitivity suggested that bonding efficiency as well as web uniformity were dominant factors influencing the fabric performance. Overall, our study demonstrated that the I/S configuration is a promising technique for the production of high strength and light weight nonwovens comprised of micro- and nanofibers.