Studies were conducted to evaluate glyphosate-, glufosiate-, and paraquat-based herbicides programs for control of glyphosate-resistant horseweed. Nonselective herbicides were applied alone or mixed with dicamba, diuron, flumioxazin, or prometryn. Glyphosate + flumioxazin + dicamba was included as a standard and a nontreated control was used. All treatments were evaluated as a stand alone burndown treatment and with a followup glufosinate burndown at planting. Glufosinate applied at planting as a followup burndown resulted in better horseweed control and increased cotton yields with all treatments except glyphosate + dicamba, glufosinate + dicamba, and glyphosate + dicamba + flumioxazin.