The University of Georgia has conducted cotton "systems trials" since 2001. This research is funded by Cotton Incorporated and the objectives of the research are to compare yield, fiber quality, costs, and net return of cotton varieties grown in accordance to their respective management regime-- conventional, herbicide resistant, insect resistant, etc. These technologies have changed over time and continue to change. Newer variations of this technology such as Roundup-Ready Flex and BollGard 2 offer more management options. Seed and associated technology fees are among the highest costs for the cotton producer. Previous research has reported that profitability is both a function of the system used as well as the choice of variety within a system. Data is examined to analyze and compare these newer technologies with previous technologies.