Field trials in Louisiana from 1995-2006 validated boll and yield tolerance to late-season cotton pests. Selected Lepidopteran and Heteropteran cotton pests were caged on cotton bolls of various ages to define the period of boll susceptibility to insect injury. Other studies evaluated insect-simulated defoliation of cotton at 66% and 99% leaf removal at selected growth stages beyond cutout to estimate yield losses. These data provide information about late-season insecticide termination strategies for selected cotton insect pests on cotton. Boll tolerance differs among all pests; therefore, boll susceptibility at various developmental stages should be determined for each cotton pest to refine late-season insect control termination strategies.