Large field scale, drip-irrigated cotton trials in 2004 and 2005 yielded an extra 250 to 450 lb of lint per acre with 6 weekly applications of Sugar MoverTM, beginning at PHS. In 2006 in a replicated experiment, Sugar MoverTM @ 1 pt/acre applied weekly for 6 weeks beginning at PHS, in a drip-irrigated trial, yielded 650 additional lb of cotton lint per acre. Seed yields were similarly increased in each study. Gene regulation studies with the model plant Arabidopsis thaliana, indicate that Sugar MoverTM up regulates sugar transporter genes by transferring sugars from the leaves to the strongest sinks, in this case the cotton bolls. Moreover, the dearth of sugar in the leaves after this sugar transfer to the phloem by enhancement of the sugar transporters, stimulates up regulation of the Rubisco gene resulting in an increase in photosynthesis of over 50%.