Field trials were conducted each year from 2003 to 2006 at locations with a history of cotton production in soils with a loamy sand texture and natural infestations of southern root knot nematode (Meloidogyne incognita). Land was prepared for planting each year by ripping and bedding rows in conventional tillage or ripping under rows in strip tillage. Each trial included four, randomized complete blocks of treatments. Varieties tested each year included DP 555 BR in 2003, ST 4892 BR in 2004, ST 449 BG/BR and ST 5599 BR in 2005, and ST 4575 BG/BR and ST 5599 BR in 2006. Plots were two, 30-ft rows spaced 36 or 38 in. apart and were planted between 29 Apr and 10 May. Seed from the same lot were planted 3 to 4 in. apart in rows each year. Avicta (abamectin 0.15 mg/seed) seed treatment was applied to seed by Syngenta Crop Protection. Treatments with Temik 15G (aldicarb 0.75 lb a.i./A) were applied to the open seed furrow at planting. Foliar sprays of Orthene 97 6 oz/A were applied to all plots on emergence of the first true leaf and repeated 2- to 3-wks later for thrips control. Thereafter, standard practices for cotton production in Virginia were followed. Plots were harvested by hand in 2003, and with a two-row mechanical harvester in 2004, 2005, and 2006. Mid- to late-season populations of southern root-knot nematode in soil were moderate to high in plots each year. A summary of results will be presented and include plant populations, growth measurements, nematode populations, root-knot gall ratings, total and open bolls, and yield.