In this presentation, we will discuss the synthesis and structural characterizations of nitro-benzyl cellulose, amino-benzyl cellulose and pentafluoro –benzyl cellulose. All cellulose derivatives are synthesized by etherification process in lithium chloride/N,N-dimethylacetamide homogeneous solution. Nitrobenzylation was effected in 80% yield by treating a mixture of microcrystalline cellulose (20μm), 4-dimethyl aminopyridine (DMAP) and 4-nitobenzyl chloride (4eq.) at 80 ºC for overnight. Nitro-benzyl cellulose was then reduced to amino-benzyl cellulose in 93% yield with indium metal in ethanol and saturated aqueous ammonium chloride. Also, the pentafluoro-benzyl cellulose was obtained by same manner. In addition to the syntheses of the desired products their structural characterizations by FT-IR, CP/MAS 13C NMR, DSC, TGA, and MALDI-TOF methods will be shown.