Research was conducted during 2004 and 2005 to compare weed management in 15 inch and 30 inch row spacing cotton. Cotton seed density was 70,000 seeds/A for both row spacings. Different levels of herbicide input were evaluated in both 15 inch and 30 inch row spacings. Weed species that were evaluated included yellow nutsedge (Cyperus esculentus L.) , sicklepod (Senna obtusifolia (L.) Irwin and Barneby), tropical spiderwort (Commelina benghalensis L.) and browntop millet (Brachiaria ramosa (L.) Stapf). When evaluated 65 days after planting, weed control averaged over all herbicide treatments was 5 to 15% better in 15 inch compared to 30 inch row spacing cotton. In general, more herbicide input was required for the 30 inch row spacing than 15 row spacing cotton to achieve acceptable levels of weed control.