Field experiments were conducted during the 2006 growing season in Leland, MS to evaluate the influence of plant population and variety on cotton response to mepiquat chloride application in an attempt to isolate a combination of these factors that will facilitate easier in-season crop management without sacrificing yield. Cotton cultivars DP 555 BG/RR, ST 6565 B2RF, and ST 4554 B2RF were planted at densities of 27,510 and 61,897 plants/A and managed using either a modified early bloom mepiquat chloride application schedule or without the use of plant growth regulators. Plant height, number of main stem nodes, internode length, NAWF, NACB, and final lint yield were measured to determine differences in plant stature and overall yield under each management regime.