An excessive amount of seed coat fragments were found in an otherwise high-quality, high-yielding cotton. Because of the increased worldwide competition for quality fibers, the cotton industry has an urgent need to determine the affects that harvesting and ginning has on cultivars with fragile seed coats. A formal experiment consisted of three harvesting treatments and three ginning treatments. The harvesting treatments included: 1) conventional 2-row picker with 1/2" spindles, 2) 1-row picker with 9/16" spindles running at normal spindle speed, and 3) 1-row picker with 9/16" spindles running at fast spindle speed. The ginning treatments included: 1) no seed-cotton cleaners in pre-cleaning, 2) three seed-cotton cleaners, and 4) six seed-cotton cleaners. Factors that will determine the treatment affects include HVI and AFIS fiber properties, and cottonseed grade analysis. The results will help determine if particular harvesting and/or ginning sequences are favorable to cultivars with fragile seed coats.