The use of fungicide, insecticide, and nematicide seed treatments in cotton production continue to grow as an accepted practice to provide protection from early season diseases, insects, and nematodes. The introduction of more precise seed treatment equipment now allows for the application of additional seed treatments such as nutritionals. It has long been an accepted practice in rice production to apply a small amount of zinc to the seed to aid in crop establishment. With the rising cost of cotton seed and associated technology fees it would be beneficial if nutritional seed treatments could enhance cotton production. The objectives of this trial were to evaluate the effect of two Teprosyn® nutritional seed treatments on cotton production. Replicated trials were conducted in Arkansas, Louisiana, Mississippi, South Carolina, and Tennessee in 2004-06. Stand establishment, growth, plant tissue levels, yield, and quality were evaluated and are presented.