During the early development of AVICTA seed treatment much testing of the activity of a range of seed and soil applied compounds were made. These compounds were tested as drench applications and/or seed treatments in tomato pot test against root-knot nematode Meloidogyne incognita Chitwood (Tylenchidae: Heteroderidae) and against Reniform nematode (Rotylenchulus reniformis) in cotton. In all, 35 compounds were screened over a two year period for their efficacy against root knot nematode. Compounds with known soil applied nematicidal activity generally did not indicate the same level of effectiveness when applied as seed treatments as compared to abamectin. Evaluations of various carbamate insecticides including aldicarb, oxamyl, methiocarb, benomyl, and thiodicarb demonstrated poor efficacy against root knot nematode when applied as a seed treatment. In conclusion, none of the insecticidal compounds tested either as soil or seed applied could provide the same level of root knot nematode control as abamectin.