Bacterial blight [caused by Xanthomonas campestris pv. malvacearum (Smith) Dye] (Xcm) can be a serious disease in most upland cotton (Gossypium hirsutum L.) growing areas of the world. While blight outbreaks are infrequent, serious epidemics can occur wherever susceptible cultivars are grown. The purpose of this study was to determine the bacterial blight resistance for 61 upland cotton cultivars. Information about their blight resistance should be useful to breeders considering various parents as sources for resistance in future cultivars. Varying numbers of cultivars (including four checks) were planted each year near Perkins, OK, over a 3-yr period. The experimental design used each year was a randomized complete-block with four replications. Two of the replications were used for testing cultivar responses to Xcm Race 1; the remaining two were used for testing responses to a mixture of races. Significant differences in blight resistance were detected among cultivars each year for both Race 1 and the race mixture. Reactions among cultivars varied from immune to fully susceptible. Cultivars included in this study were developed in seven states. The only cultivars among them with resistance or immunity to the array of races used in this study were from Texas and Oklahoma. Cultivars developed elsewhere were moderately to fully susceptible. Unless blight resistance is more widely incorporated into cotton breeding programs than it has been in the past, large areas of the Cotton Belt will remain vulnerable to outbreaks of the disease.