The number of strip-tilled cotton acres on the Texas High Plains has increased over the past few years as a means of compensating for high energy and fuel costs as well as a means of water conservation and soil erosion minimization. The development of herbicide resistant cotton varieties has facilitated the shift from conventional tillage to strip-tillage systems. As a result, weed control has become more dependent on herbicide use rather than mechanical methods. The overall objective is to evaluate different control practices for weed control effectiveness and economic efficacy. The specific objectives include: 1) using a burndown treatment in the winter or early spring to control weeds present when the strips are tilled, 2) using pre-plant incorporated herbicides applied either broadcast or in the tilled strip only to control weeds prior to planting, and using preemergence and postemergence herbicide applications following planting, 3) determining the cost per weed control system and comparing net returns above weed control costs per system, and 4) assembling a weed control recommendations guide to aid producers in strip-till cotton systems.