The reniform nematode, Rotylenchulus reniformis, has become a significant problem in many cotton fields in the Mississippi River Delta of Arkansas. Generally, cotton is grown in monoculture in the same fields year after year because it is economically attractive. However, declining yields due to the nematode warrant economical and sustainable control options. Corn and rice are not hosts for R. reniformis, and both crops are also popular in the region. Ten arbitrary sites were permanently identified with a Global Positioning System (GPS) in an infested field in Desha County, AR, in April, 2004. The field had been in cotton monoculture for at least the 10 years prior to 2004. Rice was grown in the field in 2004, and in 2005 corn was grown. Cotton was planted in the field again in 2006. Reniform nematode population densities were evaluated in each GPS site at planting and at harvest at 6-in. (15 cm) intervals vertically to a depth of 36 in. (90 cm). The objectives of this study were: i) to determine the effect of a rice-corn rotation on reniform nematode population densities and ii) to examine the residual effects of these non-host crops once cotton production had resumed.