The perennial habit of cotton allows it to regrow following harvest, providing the potential for development of hostable fruit (squares and bolls) for boll weevil feeding and reproduction. Under optimum environmental conditions, cotton plants can generate hostable fruit in three to five weeks following harvest. This provides overwintering weevils with additional food resources, enabling them to survive the winter and infest cotton fields the following spring. Early harvest and stalk destruction when performed on an area-wide basis are among the most effective practices for managing overwintering boll weevils. This is especially important in southern and eastern regions of Texas engaged in the Boll Weevil Eradication Program (~800,000 acres) because timely stalk destruction limits post-harvest spraying operations and saves the program/producers significant funds. The objective of this field study was to assess the effectiveness of 2,4-D amine and Weedmaster for post-harvest cotton stalk destruction on both shredded and standing stripper harvested stalks. Treatments included 2,4-D amine (1 lbs. ai/acre) and Weedmaster (1 lbs. ai/acre) applied to shredded and standing stalks.