Studies were conducted across the cotton growing region of the United States to evaluate and demonstrate the improved crop safety of new Roundup CROPSHIELD™ Formulations on Roundup Ready® Flex cotton. Post-emergence applications were made at crop development stages of two and eight true leaves, early bloom, and two weeks after early bloom. Visual evaluations of crop injury in the form of percent chlorosis and percent necrosis were made five days after each application. Final seedcotton yield was determined at the end of the season by mechanically harvesting each plot. All data were subjected to statistical analysis and tables constructed according to differences observed.