Cotton producers have struggled with broadleaf weed control for many years. Historically, postemergence-directed herbicides required a height differential provided using a preemergence or preplant-incorporated herbicide to suppress weed growth during the first few weeks following planting. However, most producers have faced critical weed control decisions due to the slow-growing nature of cotton during the seedling stage. Until 1997, the only option Alabama producers had for controlling broadleaf weeds with postemergence over-the-top herbicide application severely injured cotton and delayed maturity. The widespread success of glyphosate-based management programs has also resulted in an increase of difficult to control weeds and weed resistance in some areas of the southeastern U.S. A study was initiated in 2006 in central Alabama to evaluate the effect of tillage in combination with various herbicide programs on redroot pigweed management in cotton.