Cotton defoliation is a complex process where not only leaf drop is expected but also the process of boll opening. The ability to use one product one time is often not possible with the various conditions experienced in the real world of commercial cotton production. Micro Flo Company has evolved formulation technology Harvest - Smart Science, that greatly enhances the performance of both cotton boll opening and defoliant compounds. Efficacy data for two new novel formulations conducted by University and Independent Crop Consultant replicated trials, as well as commercial production fields across the Cotton Belt wil be presented. Both products will be commercially available in 2006