The mode-of-action of the insecticidal crop protection product, flonicamid, has not been elucidated at this time. However, various enzyme assays, ligand binding studies, neurophsiology, genetic assays, and phenotypic observations rule out all know insecticide mode-of-actions. For these reasons, we are convinced that flonicamid represents a novel mode-of-action. Because of its efficacy, high safety profile for both beneficial insects and environmental toxicology (fish, birds, and mammals), and unique mode-of-action, we believe flonicamid will be a valuable IPM tool for controlling piercing/sucking insects.