Field tests during 2005 were conducted near College Station, TX to study the effect of multiple bacterial blight (Xanthomonas campestris) applications on cotton lint yield and fiber properties. Yield and fiber data were collected from replicated plots treated with a mixture of X. campestris races during the 5 and 8 true leaf stages. Methods to control bacterial blight are generally preventative and the most effective initial choice that a producer has control over is the selection of resistant cultivars. Therefore, four cultivars representing a range of susceptibility to bacterial blight were used in this study to show effect of treatment by genotype interaction and the importance of selecting cultivars resistant to bacterial blight.