Research in Florida has indicated that the application of foliar fungicides during flowering reduces the incidence of hardlock and increases yield. This result has not been documented in other areas of the cotton belt, specifically South Carolina. The primary objective of this study was to evaluate Topsin M at various rates and timings to determine its effectiveness in controlling hardlock and subsequently increasing yields. Sprays were initiated at flowering to determine if Topsin M has any direct effects on plant growth and development that could result in enhanced yields. This trial was conducted in 2004 and 2005 at the Edisto Research and Education Center in Blackville, South Carolina.