Research was conducted at the Dean Lee Research Station, Alexandria, LA, and at the Northeast Research Station, St. Joseph, LA, in 2005 to determine residual weed control effectiveness from selected cotton herbicides. Herbicides chosen included fluometuron, pyrithiobac sodium, trifloxysulfuron-sodium, and pendimethalin. These herbicides were applied PRE alone and in combination with metolachlor. Ratings were taken at 7, 14, 28, and 56 days after treatment. Length of herbicide activity was also recorded from application timing to the first application of glyphosate applied POST. Treatments were also harvested for yield differences. The objective of this study was to determine the length of residual weed control seen from these commonly used herbicides. Once added to a cotton weed control program, PRE herbicides can offer growers an added benefit of weed control through residual activity.