Several previous reports have documented the theoretical and experimental errors associated with EPA approved PM10 and PM2.5 ambient air samplers. The theoretical and experimental over-sampling rates for the PM10 and PM2.5 samplers have been shown to exceed 300 and 1,400%, respectively. The purpose of this manuscript is to explain how these errors can affect the regulatory process and agricultural industries. A simplified view of the regulatory process will be taken, so that the discussions are limited to how the sampler errors impacted receptor site monitoring, how this monitoring affects or leads to the development of state implementation plans, and how these plans could ultimately affect agricultural operations.