The primary goal of this research was to determine optimum processing conditions to produce commercially acceptable melt blown (MB) and spunbond polymer-laid thermoplastic polyurethane (TPU) nonwoven fabrics. The 20-inch wide Accurate Products MB pilot line at the Textiles and Nonwovens Development Center (TANDEC), The University of Tennessee, Knoxville, was utilized for this study. MB TPU webs having small fiber diameters were obtained from film-forming and highly elastic fiber-forming TPUs and the webs were mechanically stronger and more durable to abrasion compared to MB PP. Different TPU polymers responded very differently to MB processing and exhibited different web structure and properties, although uniform elastic MB webs were produced with average fiber diameters in the range of 4-6 µm. SB TPU trials were also made on the one-meter Reicofil® 2 SB line at TANDEC with the goal of producing even stronger TPU fabrics that can be laminated with MB TPU for better cover and with cotton fibers for enhanced comfort. This research was funded in part by a grant from the Army Research Office (ARO) and the findings were used by ARO towards the development of an elastic chemical protective liner with better overall comfort attributes and protection against chemical warfare agents.