An unusual amount of seed coat fragments were found in a newly-developed California cotton. Because of the increased worldwide competition for quality fibers, the cotton industry has an urgent need to determine the effects that harvesting and ginning has on varieties with fragile seed coats. A formal experiment consisted of three harvesting treatments and four ginning treatments. The harvesting treatments included: 1) standard 4-row picker with a control variety, 2) standard 2-row picker with the problem variety, 3) 1-row picker running at standard spindle speed with the problem variety, and 4) 1-row picker running at high spindle speed with the problem variety. The ginning treatments included: 1) 46-saw stand with seed roll conveyor tube running at standard ginning rate, 2) 46-saw stand with seed roll conveyor tube running at slow ginning rate, 3) 93-saw stand with conventional roll box running at standard speed, and 4) 110-saw stand with Power Gin Roll. Results to be presented included HVI, AFIS, and strength of attachment fiber properties, and cottonseed grade analysis. The results will help determine if particular harvesting and/or ginning sequences are favorable to varieties that contain fragile seed coats.